{"id":3075,"date":"2026-02-20T14:46:37","date_gmt":"2026-02-20T13:46:37","guid":{"rendered":"https:\/\/www-preprod.cnrs-imn.fr\/anr-smarties\/"},"modified":"2026-04-01T11:59:51","modified_gmt":"2026-04-01T09:59:51","slug":"anr-smarties","status":"publish","type":"page","link":"https:\/\/www.cnrs-imn.fr\/en\/projects-collaborations\/academic-projects\/anr-smarties\/","title":{"rendered":"ANR SMARTIES"},"content":{"rendered":"

ANR project<\/p>\n<\/div>

Design of injectable hydrogels based on a Smarties marine exopolysaccharide for osteoarticular engineering<\/h2><\/div>
<\/div><\/div>

Dates:<\/strong>
\nOctober 2022 – February 2027<\/p>\n

Project coordinator:<\/strong>
\nInstitut Francais de Recherche pour l’Exploitation de la Mer (IFREMER Nantes)<\/p>\n

Partner laboratories :<\/strong><\/p>\n

    \n
  • IMN<\/li>\n
  • Inserm RMeS Nantes<\/li>\n<\/ul>\n

    IMN staff involved:<\/strong>
    \nSt\u00e9phane CUENOT, Jean LE BIDEAU<\/p>\n<\/div>

    <\/div><\/div>

    Articular cartilage damage remains a clinical challenge. Current surgical treatments, including cellular therapies, allow only partial recovery of joint function. <\/p>\n

    The aim of this project is to explore a cell-free strategy by designing an innovative hydrogel to recruit progenitor cells and stimulate their differentiation into a cell line suitable for regenerating both cartilage and subchondral bone. In this context, a new injectable hydrogel based on a marine bacterial exopolysaccharide with glycosaminoglycan-mimetic properties will be developed. The efficacy of this hydrogel, enriched with microparticles containing growth factors, in repairing osteoarticular defects will be evaluated in preclinical trials. <\/p>\n

    This project represents an important milestone in the treatment of cartilage lesions, and will open up a new avenue for future clinical trials.<\/p>\n<\/div>

    <\/span><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":3331,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-3075","page","type-page","status-publish","hentry"],"yoast_head":"\nANR SMARTIES - IMN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cnrs-imn.fr\/en\/projects-collaborations\/academic-projects\/anr-smarties\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ANR SMARTIES - IMN\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cnrs-imn.fr\/en\/projects-collaborations\/academic-projects\/anr-smarties\/\" \/>\n<meta property=\"og:site_name\" content=\"IMN\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-01T09:59:51+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"11 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.cnrs-imn.fr\\\/en\\\/projects-collaborations\\\/academic-projects\\\/anr-smarties\\\/\",\"url\":\"https:\\\/\\\/www.cnrs-imn.fr\\\/en\\\/projects-collaborations\\\/academic-projects\\\/anr-smarties\\\/\",\"name\":\"ANR SMARTIES - 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