{"id":3171,"date":"2026-02-20T16:27:09","date_gmt":"2026-02-20T15:27:09","guid":{"rendered":"https:\/\/www-preprod.cnrs-imn.fr\/anr-azotics\/"},"modified":"2026-04-01T11:59:51","modified_gmt":"2026-04-01T09:59:51","slug":"anr-azotics","status":"publish","type":"page","link":"https:\/\/www.cnrs-imn.fr\/en\/projects-collaborations\/academic-projects\/anr-azotics\/","title":{"rendered":"ANR AZOTICS"},"content":{"rendered":"

ANR project<\/p>\n<\/div>

Photostimulable nanoparticles for imaging inflammation in microvascular systems by high-contrast photoacoustic microscopy<\/h2><\/div>
<\/div><\/div>

Dates:<\/strong>
\nJanuary 2021 – December 2025<\/p>\n

Project coordinator:<\/strong>
\nChemistry and Interdisciplinarity, Synthesis, Analysis, Modeling (CEISAM Nantes)<\/p>\n

Partner laboratories :<\/strong><\/p>\n

    \n
  • IMN<\/li>\n
  • Interdisciplinary Physics Laboratory (LIPHY Saint Martin d’H\u00e8res)<\/li>\n
  • Nantes Angers Cancer and Immunology Research Center (CRCINA Nantes)<\/li>\n
  • Techniques de l’Ing\u00e9nierie M\u00e9dicale et de la Complexit\u00e9 – Informatique, Math\u00e9matiques et Applications (TIMC-IMAG Grenoble)<\/li>\n<\/ul>\n

    IMN staff involved:<\/strong>
    \nSt\u00e9phane CUENOT<\/p>\n<\/div>

    <\/div><\/div>

    The recent emergence of high-resolution, in-depth imaging techniques such as photoacoustic microscopy (PA) is opening up new fields of biological investigation. The in vivo monitoring of immune cells, markers of inflammation and severe pathologies, is one such area of interest. The interdisciplinary AZOTICS project aims to overcome the current limitations of PA microscopy by developing innovative biocompatible elastomer nanolabels based on azo photochromes. Photostimulated actuation mechanisms will be used to amplify PA contrast based on thermal expansion. Photoinduced mechanical deformations of single nano-objects will be assessed by atomic force microscopy. Their PA imaging properties will be studied via a continuum in vitro, in cellulo and in vivo, using monocyte and macrophage labeling, microfluidic systems mimicking microvascularization, and inflammatory models.<\/p>\n<\/div>

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